Ion irradiation is a promising tool to emulate neutron-irradiation effects on reactor pressure vessel (RPV) steels, especially in the situation of limited availability of suitable neutron-irradiated material.This approach requires the consideration of ion-neutron transferability issues, which are addressed in the present study by comparing the effe
Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas
Background: Intra-tumoral CD8 + T-cell infiltration in squamous cell carcinoma of the head and neck (HNSCC) has previously been linked to the efficacy of cisplatin-based chemoradiation (CDDP-CRTX) and immune checkpoint inhibitor (ICI) monotherapy.Further detailed characterization of the tumor immune-micromilieu and its influence on outcome may guid
Higher PEEP improves outcomes in ARDS patients with clinically objective positive oxygenation response to PEEP: a systematic review and meta-analysis
Abstract Background Mortality in patients with acute respiratory distress syndrome (ARDS) remains high.These patients require mechanical ventilation strategies that include high positive end-expiratory pressure (PEEP).It remains controversial whether high QUICK D PEEP can improve outcomes for ARDS patients, especially patients who show improvement
Isomer-Resolved Imaging of Prostate Cancer Tissues Reveals Specific Lipid Unsaturation Profiles Associated With Lymphocytes and Abnormal Prostate Epithelia
Prostate cancer is the fourth most common cancer worldwide with definitive diagnosis reliant on biopsy and human-graded histopathology.As with other pathologies, grading based on classical haematoxylin and eosin (H&E) staining of formalin fixed Order Racks paraffin-embedded material can be prone to variation between pathologists, prompting inve